Proteomic Testing for Targeted Therapy in Non-Small-Cell Lung Cancer

Identification of a Novel Tumor-Binding Peptide for Lung Cancer Through in-vitro Panning

Tumor-targeted therapies are playing growing roles in cancer research. The exploitation of these powerful therapeutic modalities largely depends on the discovery of tumor-targeting ligands. Phage display has proven a promising high throughput screening tool for the identification of novel specific peptides with high binding affinity to cancer cells. In the present study, we describe the use of ...

Identification of a Novel Tumor-Binding Peptide for Lung Cancer Through in-vitro Panning

Tumor-targeted therapies are playing growing roles in cancer research. The exploitation of these powerful therapeutic modalities largely depends on the discovery of tumor-targeting ligands. Phage display has proven a promising high throughput screening tool for the identification of novel specific peptides with high binding affinity to cancer cells. In the present study, we describe the use of ...

Proteomic Testing for Targeted Therapy in Non-Small-Cell Lung Cancer

Proteomic Testing for Targeted Therapy in Non-Small-Cell Lung Cancer

Populations Interventions Comparators Outcomes Individuals: With EGFR-negative or EGFRstatus unknown non-small-cell lung cancer with disease progression after first-line treatment Interventions of interest are: Management with a serum proteomic test to select targeted therapy Comparators of interest are: • Standard medical management Relevant outcomes include: • Overall survival • Disease-speci...

Preparation and in-vitro Evaluation of an Antisense-containing Cationic Liposome against Non-small Cell Lung Cancer: a Comparative Preparation Study

The current methods for treatment of cancers are inadequate and more specific methods such as gene therapy are in progress. Among different vehicles, cationic liposomes are frequently used for delivery of genetic material. This investigation aims to prepare and optimize DOTAP cationic liposomes containing an antisense oligonuclotide (AsODN) against protein kinase C alpha in non-small cells lung...